damtree.pages.dev

Calmette pronunciation

    •

Albert Calmette

French physician and immunologist (1863–1933)

Léon Charles Albert CalmetteForMemRS[1] (French pronunciation:[leɔ̃ʃaʁlalbɛʁkalmɛt]; 12 July 1863 – 29 October 1933) was a French physician, bacteriologist and immunologist, and an important officer of the Pasteur Institute. He co-discovered the Bacillus Calmette-Guérin, an attenuated form of Mycobacterium bovis used in the BCGvaccine against tuberculosis. He also developed the first antivenom for snake venom, the Calmette's serum.

Early career

Calmette was born in Nice, France. He wanted to serve in the Navy and be a physician, so in 1881 he joined the School of Naval Physicians at Brest. He started to serve in 1883 in the Naval Medical Corps in Hong Kong, where he worked with Dr Patrick Manson, who studied the mosquito transmission of the parasitic worm, filaria, the cause of elephantiasis. Calmette completed his medical degree on the subject of filariasis.[2] He was then assigned to Saint-Pierre and Miquelon, where he arrived in 1887. Afterwards, he served in West Africa

    •

Doctor Albert Calmette 1863-1933: founder of antivenomous serotherapy and of antituberculous BCG vaccination

In 1891 in Saigon (now Ho Chi Minh City), Dr. Albert Calmette established the first daughter Pasteur Institute for the protection of the local population against rabies and smallpox. Inspired by the discovery of diphtheria antitoxin by Behring, Calmette studied ways of raising serum against cobra venom. In 1895, now in Lille at the second daughter institute that he established, Calmette produced anticobra serum for therapeutic use that was to revolutionize the treatment of snakebite worldwide. The incidence of tuberculosis in the working class of the industrial north shocked Calmette. In response, firstly he organized an antituberculous dispensary to provide assistance to the sick and help limit the spread of the disease by improving social hygiene and secondly he devoted himself, with the assistance of Camille Guérin, to obtaining an attenuated live strain of tubercle bacilli with fixed biological characteristics for use as a vaccine. Such a strain developed during rep

    •

Albert Calmette (1863-1933) and Camille Guérin (1872-1961): the C and G of BCG vaccine

Early in his medical career, Albert Calmette showed a remarkable aptitude for bacteriology and, in 1891, he opened the first daughter Pasteur Institute in Saigon, French Indochina at the request of Louis Pasteur. In 1894, at the Pasteur Institute in Paris, Calmette succeeded in developing an antiserum to cobra venom and so initiated antivenomous serotherapy. In 1895 Calmette was asked to found a second daughter, Pasteur Institute in Lille. Soon he was joined by the young veterinarian, Camille Guérin, and so began a unique partnership, the two men striving to free people from the dreadful scourge of tuberculosis. Investigating the intestinal route of tuberculous infection, Calmette and Guérin began to grow Mycobacterium tuberculosis bovis in a beef bile-glycerine medium. With continuous replanting of the culture in this medium (from 70 to 235 times), an attenuated bacillus of fixed properties was discovered; this Calmette called Bacille-Calmette-Guérin (BCG). Exhaustive testing of BCG showed

Copyright ©damtree.pages.dev 2025