Proton k&d lang biography
- K.d.
- Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is unique.
- Reported neurotoxicity resulting from proton radiation treatments include radiation necrosis, moyamoya syndrome, neurosensory toxicities, brain edema.
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Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family
Abstract
Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is unique. HV channels are perfectly selective for protons and have a very small unitary conductance, both arguably manifestations of the extremely low H+ concentration in physiological solutions. They open with membrane depolarization, but their voltage dependence is strongly regulated by the pH gradient across the membrane (ΔpH), with the result that in most species they normally conduct only outward current. The HV channel protein is strikingly similar to the voltage-sensing domain (VSD, the first four membrane-spanning segments) of voltage-gated K+ and Na+ channels. In higher species, HV channels exist as dimers in which each protomer has its own conduction pathway, yet gating is cooperative. HV channels are phylogenetically diverse, distributed from humans to unicellular marine life, and perhaps even plants. Correspondingly, HV functions vary widely as well, from pr
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Hello there! In this week’s blog we will discuss the song Hallelujah. This has to be one of the most frequently-covered songs of all time. We will review the original written by Leonard Cohen. We will then discuss covers of this song by Jeff Buckley and by k. d. lang.
Leonard Cohen passed away on November 7, 2016. As we will see, Cohen was a man of many talents. We want to dedicate this blog post to our good friend Merle McClung, whom we met when we were in graduate school. Cohen’s song Democracy (Is Coming to the USA) is one of Merle’s favorite songs. So, this post is for you, Merle.
Leonard Cohen, Hallelujah:
Leonard Cohen was a multi-talented artist. He began his career as a poet and novelist, but then branched out to become a singer-songwriter.
Cohen was born in 1934 to a middle-class Jewish family in an English-speaking area of Montreal. Cohen’s paternal grandfather had been the founder of the Canadian Jewish Congress.
Below is a photo of Leonard Cohen performing at the Isle of Wight Festival in August 1970.
Embed from Getty ImagesWhile a student at McGill Unive
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